What does science tell us about boxing’s gender row?

There are some people born with XY chromosomes who have lost what Dr Hilton calls the "make-male" gene.

“These people don’t make testosterone. They develop a very typical female anatomy,” Dr Hilton says.

So a test that identifies XY chromosomes does not offer a complete picture. And in the case of Imane Khelif and Lin Yu-ting, the IBA has not disclosed details of the way they were tested.

However, Dr Hilton also says that in most people with XY chromosomes, the SRY "make-male" gene is present.

These people usually have testicles which are often inside the body.

“When they hit puberty they start producing testosterone - which is what underpins male advantage in sports," says Dr Hilton.

The most famous example is Caster Semenya - a double Olympic gold medallist and three-time world champion over 800m, though Prof Alun Williams says there is not direct evidence that DSD athletes have the same advantage as typical males.

The roadblock is in a gene required to generate external genitalia - which boys need in order to grow a penis. Anyone with the same condition as Caster Semenya has a mutation within that gene that stops it functioning normally.

In the womb, they will develop a male anatomy until the final stage of growing a penis - and when they are not able to, then they’ll start developing a vulva and a clitoris.

But they don’t develop female reproductive organs: they don’t have a cervix or a uterus.

These people don’t have periods and they can’t get pregnant. Having sex with males can be difficult.

Discovering you have this kind of genetic mutation can be a shock.

“The most recent woman we diagnosed with having XY chromosomes was 33,” says Claus Højbjerg Gravholt - an endocrinology professor at Aarhus University who spent the past 30 years dealing with DSD.

His patient came to see him because she had no idea why she couldn’t get pregnant.

“We discovered she didn’t have a uterus, so she would never be able to have a baby. She was absolutely devastated.”

Prof Gravholt says the implications that come with questioning one’s gender identity can be destabilising - and he often refers his patients to a psychologist.

“If I showed you her photo, you would say: that’s a woman. She has a female body, she is married to a man. She feels like a female. And that is the case for most of my patients.”

When Prof Gravholt asked her why she didn’t consult a doctor about not getting periods, she said there was another older woman in her family who never menstruated - so she thought it wasn’t abnormal.

There is another genetic mutation Prof Gravholt has come across.

He has diagnosed males who have XX chromosomes - which are normally found in females. “These men are infertile. They look like normal males, but their testes are smaller than average and don’t produce sperm. It’s always devastating when they find out. As they grow older, they stop producing testosterone in the way most men do.”

In some cultures, talking openly about periods and female anatomy is not culturally acceptable. In some parts of the world, women may lack the education to understand that there’s something atypical going on in their bodies.

And that’s why experts believe that many DSDs are never diagnosed - which means that comprehensive data is scarce.

But Prof Gravholt points to figures from Denmark as a good indicator.

“Denmark is probably the best country in the world at collecting this data - we have a national registry with everyone who has ever had a chromosome examination.”

He says that XY chromosomes in females are very rare - in Denmark it’s about one in 15,000.

But he believes that when adding these many genetic conditions together, about one in 300 people are affected.

“We are learning that these variations are more common than we thought,” Prof Gravholt says. “A lot of patients are being diagnosed later in life. The oldest person I diagnosed was a male in his 60s.”

Do people with differences of sex development have an unfair advantage in sport? The short answer is that there is not enough data to reach a definitive conclusion.

“It wouldn’t surprise me if some people with a type of DSD had some physical advantage over women,” says Prof Alun Williams. Those advantages could include larger muscle mass, as well as bigger and longer bones and larger organs such as lungs and heart.

He says they may also have higher levels of blood haemoglobin that lead to improved oxygen delivery to where it’s needed in working muscles.

"Some people with some types of DSDs might have advantages in some or all of those elements, ranging from 0-100%, depending on the type of DSD and its precise genetic cause."

He believes his opinion is representative of the experts in his field, but that more evidence is needed.

When it comes to Imane Khelif and Lin Yu-ting, we don’t have enough information to know if they have a DSD that would need to be regulated.

Regulating elite sports, which typically rely on male-female binary categories in competition, is complicated because the biology of sex itself is complex.

Dr Shane Heffernan has a PhD in molecular genetics in elite sports and is currently working on a paper on what athletes think about competitors with a DSD.

He says it’s all about the nuance of the individual’s genetic condition.

For example, females with a DSD known as androgen insensitivity syndrome have XY chromosomes; they produce testosterone; but their bodies aren’t equipped to process it. So they don’t get any of the benefits from that testosterone, like males do.

Dr Heffernan says that there aren’t enough known and studied athletes with a DSD to make a valid scientific conclusion as to whether they definitely have an advantage, and as to whether they should be eligible or ineligible to compete in the female category.

He believes that the International Olympic Committee is not basing its eligibility criteria on the best available science.

“This is worrying. The IOC makes an 'assumption of no advantage' - but there is no direct evidence for this, nor that there is a performance advantage with DSD athletes solely because of their genetic variations.

“We simply don’t have enough data. Many people hold an emotional position when it comes to inclusion in the female category, but how can the IOC justify this position - without the data to support it?”

He is one of many people who are urging the Olympics committee, international federations and funding councils to invest in research on athletes with a DSD - but he appreciates it’s difficult, because there can be a lot of stigma towards the individual athletes when it comes to these conditions.

Some are calling for mandatory sex testing at the next Olympics - including Reem Alsalem, the UN’s special rapporteur on violence against women and girls.

“Screening DNA is now a piece of cake,” Dr Emma Hilton says. “A simple cheek swab would be sufficient, and it’s minimally invasive.”

She says swabs should happen when athletes first register for their first affiliated competition - before they start winning medals and the spotlight hits them, so as to avoid what happened with Imane Khelif.